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G. Kerr Whitfield, PhD

Assistant Professor and Lecturer, Department of Basic Medical Sciences - The University of Arizona College of Medicine—Phoenix
Phone: 
(602) 827-2142
Email: 
gkw@email.arizona.edu
UA Office Building and Room : 
Building ABC1, Room 426
Education: 
PhD; North Carolina State University at Raleigh
Research
  • Target genes for 1,25-dihydroxyvitamin D3, the hormonal form of vitamin D
  • Evolution of the vitamin D receptor, a member of the nuclear receptor superfamily
  • Analysis of naturally-occuring mutations in the vitamin D receptor that lead to vitamin D-resistant rickets
  • Mutagenesis studies of the vitamin D receptor as informed by evolutionary comparisons and by analysis of published 3-D crystallographic structures
  • Role of vitamin D receptor in regulating epidermal genes to improve symptoms of psoriasis and other skin disorders

     
G. Kerr Whitfield, PhD
Selected Publications

PubMed Link:

Search PubMed for a complete listing of Dr. Whitfield's publications

  1. Hsieh JC, Slater SA, Whitfield GK, Dawson JL, Hsieh G, Sheedy C, Haussler CA, Haussler MR. Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle. J Cell Biochem. 2010 110(3):671-686.
  2. Haussler MR, Haussler CA, Whitfield GK, Hsieh JC, Thompson PD, Barthel TK, Bartik L, Egan JB, Wu Y, Kubicek JL, Lowmiller CL, Moffet EW, Forster RE, Jurutka PW. The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging. J Steroid Biochem Mol Biol. 2010 121(1-2):88-97.
  3. Whitfield GK, Jurutka PW, Haussler CA, Hsieh JC, Barthel TK, Jacobs ET, Encinas Dominguez C, Thatcher ML, Haussler MR 2005 Nuclear vitamin D receptor: structure-function, molecular control of gene transcription, and novel bioactions In: Feldman D, Pike JW, Glorieux FH eds. Vitamin D. 2nd ed. Oxford, UK: Elsevier Academic Press; 219-261
  4. Whitfield GK, Dang HT, Schluter SF, Bernstein RM, Bunag T, Manzon LA, Hsieh G, Dominguez CE, Youson JH, Haussler MR, Marchalonis JJ. 2003 Cloning of a functional vitamin D receptor from the lamprey (Petromyzon marinus), an ancient vertebrate lacking a calcified skeleton and teeth. Endocrinology. 2003 144:2704-2716.
  5. Makishima M, Lu TT, Xie W, Whitfield GK, Domoto H, Evans RM, Haussler MR, Mangelsdorf DJ. 2002 Vitamin D receptor as an intestinal bile acid sensor. Science. 296:1313-1316.
  6. Whitfield GK, Selznick SH, Haussler CA, Hsieh J-C, Galligan MA, Jurutka PW, Thompson PD, Lee SM, Zerwekh JE, Haussler MR 1996 Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D3: point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner. Mol Endocrinol 10:1617-1631