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Gholam Peyman, PhD

Professor, Department of Optical Sciences - UA College of Medicine
Background: 

Gholam A. Peyman, MD is a Hall of Fame [3]of Ophthalmologyand retina surgeon who is also a prolific and successful inventor. Gholam Peyman has, thus far, been granted 150 US patents [4]covering a broad range of novel medical devices, intra-ocular drug delivery, surgical techniques, as well as new methods of diagnosis and treatment. His most widely-known invention to date is LASIKeye surgery,[5]a revolutionary vision correction procedure which has enabled tens of millions of people to see clearly without glasses, for which he was awarded the first US patent in 1989 (link to image of patent, below). In addition to the numerous other honors and awards he has received (please see section 4, for Publications and awards), in 2005 he was selected by a ballot among the more than 30,000 ophthalmologists around the world to become one of the thirteen living ophthalmologists inducted into the Hall of Fame of Ophthalmology.[6]

Life and career

Peyman was born in Iran. At the age of 19, he moved to Germanyto begin his medical studies. He received his MD at the University of Freiburgin 1962. He completed his internship at St. Johannes Hospital in Diusberg, Germany in 1964 and at Passaic General Hospital in Passaic, New Jerseyin 1965. Peyman completed his residency in ophthalmology and a retina fellowship at the University of Essen, Essen Germany, in 1969 and an addiional postdoctoral fellowship in retina at the Jules Stein Eye Institute, UCLA School of Medicine in Los Angeles in 1971. Peyman held the position of Assistant Professor of Ophthalmology at the UCLASchool of Medicine from 1971 and served as Associate Professor and then Professor of Ophthalmology at the Abraham Lincoln School of Medicine, University of Illinois at Chicagoduring 1971-1987. Peyman held a joint appointment at the School of Medicine and also at the Neuroscience Center of Excellence at the Louisiana State University Medical University Medical Center in New Orleans during 1987-2000. During 1998-2000 Peyman held the Prince Abdul Aziz Bin Ahmed Bin Abdul Aziz Al Saud Chair in Retinal Diseases. During 2000-2006, Peyman served as Professor of Ophthalmology and Co-Director, Vitreo-Retinal Service, TulaneUniversity School of Medicine in New Orleans. During 2006-2007 he was Professor of Ophthalmology at the University of Arizona, Tucson with a cross appointment at University of Arizona Optcal Sciences. He has been emeritus Professor of Ophthalmology at Tulane University since 2009. Peyman is currently Professor of Basic Medical Sciences at the University of Arizona, Phoenix & Optical engineering at U.A. Tucson AZ.

Peyman evaluated the application of topical cyclosporine to the cornea prior and postsurgery in LASIK patients. He was able to convincingly demonstrate in a controlled clinical study that its use dramatically accelerates the return of corneal sensitivity after LASIK surgery when compared to the contra-lateral control eye (which received LASIK surgery but not cyclosporine). In 2008 Peyman was awarded the Waring medal by a leading peer-reviewed ophthalmology journal for this breakthrough invention [10](please also see 4 Publications and awards). Figure 1. Dr. Peyman's patent was the first to describe what has become one of the most popular and effective elective surgical procedures in history: Laser-Assisted In situ Keratomileusis, more commonly known as LASIK surgery.

Other Inventions and patents

Peyman's inquiring mind, coupled with his keen interest in engineering and pharmacology along with his in-depth background and experience in ophthalmology resulted, over a 40-year period, in a remarkable range of novel devices, improvements in surgical methods and revolutionary new treatment methods and modalities. A partial list of Peyman's most significant discoveries and inventions (with first publication date), many of which are still in use today, includes: Modifica8ons and improvements to the operating microscope (1972, 1974 and 1977)[11]Vitrectomy instruments and techniques - Techniques of vitreous removal (1971, 1972) [12]- Vitreous scissors and forceps (1975) [13]- The vitrophage (1976, 1977) [14]- Improved vitrectomy illumination system (1976) [15]- Wide-angle cutter vitrophage (1976) [16]- Miniaturization of the vitrophage (1980) [17]- A bent-.pped vitrophage for anterior segment surgery (1982) [18]- An illuminated air-fluid switch for vitrectomy (1988) [19]- A miniaturized vitrectomy system (23 gauge) for vitreous and retinal biopsy (1990) [20]- A pneumovitrector for diagnostic biopsy of the vitreous (1996) [21]- A new high-speed pneumatic vitrectomy cutter (2002) [22]- Small-size pediatric vitrectomy wide-angle contact lens (2003) [23]- A new, non-contact wide-field viewing system for vitreous surgery (2003) [24]Endolaser for vitrectomy - Intraocular photocoagulation with the argon-krypton laser (1980) [25]- Argon endolaser (1981) [26]- A microscope filter for endophotocoagula.on (1981) [27]- Protective eye filters for endolaser therapy (1986) [28]- Special short needles to inject and aspirate high-viscosity sililcone oil (1986) [29]- Contact lenses for Nd-YAG application in the vitreous (1984) [30]- A new contact lens for Nd:YAG laser capsulotomy (1986) [31]- An automatic laser filter for the indirect ophthalmoscope (1987) [32]- A bent-tipped endolaser probe (1987) [33]- An endolaser probe with aspiration capability (1992) [34]Vitreous subs8tutes - Evalua.on of perfluourocarbon gases in the vitreous (1973) [35]- Use of fluorosilicone to unfold a giant retinal tear (1987) [36]- Injec.on of fluorosilicone oil and pars plana vitrectomy for complex retinal detachment (1987) [37]- Experimental evaluation of perfluorophenanthrene as a high specific gravity vitreous substitute (1989) [38]- Perfluorocarbon liquids in ophthalmology (1995) [39]Eye wall resection (tumors) and biopsy - Full thickness eye wall resection (1972) [40]- Local excision of choroidal malignant melanoma: Full thickness eye wall resection (1974) [41]- Biopsy of human scleral-chorioretinal tissue (1975) [42]- Abinterno resection of uveal melanoma - Histopathology of Goldmann-Favre syndrome obtained by full-thickness eye-wall biopsy (1977) [43]- Full thickness eye wall resection of choroidal neoplasms (1979) [44]- Treatment of large von Hippel tumors by eye wall resection (1983) [45]- Internal retinal biopsy: Surgical technique and results (1990) [46]Surgical and pharmaceu8cal treatments for bacterial endophthalmi8s (numerous publica.ons 1973-1982) [47]Pressure-controlled shunt for glaucoma - An experimental "aqueous shunt" for the regulation of intraocular pressure. (1974) [48]- Experimental evaluation of a posterior drainage system. (1983) [49]The first ultraviolet light-absorbing - Ultraviolet light absorbing pseudophakos (1982) [50]intra-ocular lens (IOL) Intravitreal antineoplas8c (cancer) - Toxicity of antineoplas.c drugs in vitrectomy infusion fluids (1983 and 1984) [51]drugs Combination intravitreal therapy - Bacterial endophthalmi.s: Treatment with intraocular injection of gentamicin and dexamethasone (1974) [52]- Toxicity of antibio.c combinations for vitrectomy infusion fluid (1979) [53]- Toxicity of antineoplastic drug combinations in vitrectomy infusion fluid (1984) [54]- In vitro evalua.on of cellular inhibitory potential of various antineoplastic drugs and dexamethasone (1985) [55]- Proliferative vitreoretinopathy and chemotherapeutic agents (1985) [56]- Effects of selected repeated intravitreal chemotherapeutic agents (1985) [57]- Toxicity and clearance of a combination of liposome-encapsulated ganciclovir and trifluridine (1989) [58]Intravitreal effects of antiviral drugs - Toxicity of intravitreal antiviral drugs (1984) [59]- Vitrectomy and intravitreal antiviral drug therapy in acute retinal necrosis syndrome. Report of two cases. (1984) [60]- Parenterally-administered acyclovir for viral retinitis associated with AIDS (1984) [61]- Intravitreal toxicity of hydroxyacyclovir (BW-B759U), a new antiviral agent (1985) [62]- Retinal toxicity of ganciclovir in vitrectomy infusion solution (1987) [63]- Toxicity of intravitreal injection of foscarnet in the rabbit eye (1988) [64]- Retinal toxicity of 6-methoxypurine arabinoside (Ara-M): A new selec.ve and potent inhibitor of varicella-zoster virus (1992) [65]Intravitreal immunosuppressants - Retinal toxicity study of intravitreal cyclosporine (1986) [66]- Liposome-bound cyclosporine: Retinal toxicity afer intravitreal injec.on (1988) [67]- Ocular toxicity of intravitreal tacrolimus (2002) [68]Slow release ocular drug delivery - Intravitreal liposome- encapsulated gentamicin in a rabbit model: Prolonged therapeutic levels (1986) [69]- Liposome- encapsulated 5-fluorouracil in the treatment of prolifera.ve vitreore.nopathy (1988) [70]- Intravitreal liposome-encapsulated drugs: A preliminary human report (1988) [71]- Clearance of sodium fluorescein incorporated into microspheres from the vitreous ager intravitreal injec.on (1991) [72]- Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates (1992) [73]First attempt to correct refractive - Modifica.on of rabbit corneal curvature with use of carbon dioxide laser burns (1980) [74]errors using lasers Evalua8ons of laser use in ophthalmology - Histopathological studies on transscleral argon-krypton laser coagula.on with an exolaser probe (1984) [75]- Comparison of the effects of argon fluoride (ArF) and krypton fluoride (KrF) excimer lasers on ocular structures (1985) [76]- The Nd:YAG laser 1.3µ wavelength: In vitro effects on ocular structures (1987) [77]- Effects of an erbium:YAG laser on ocular structures (1987) [78]- Contact laser: Thermal sclerostomy ab interna (1987) [79]- Internal trans-pars plana filtering procedure in humans (1988) [80]- Internal pars plana sclerotomy with the contact Nd:YAG laser: An experimental study (1988) [81]Intraocular telescope for age related - Age-related macular degeneration and its management (1988) macular degenera8on Retinal pigment epithelium - A technique for retinal pigment epithelium transplantation for age-related macular degenera.on secondary to extensive subfoveal scarring (1991) transplanta8on Photodynamic therapy for ARMD - The effect of light-activating .n ethyl etiopurpurin (SnET2) on normal rabbit choriocapillaries (1996) - Problems with and pitfalls of photodynamic therapy (2000) Semiconductor photodiode stimulation - Subre.nal semiconductor microphotodiode array (1998) of the re8na - Subretinal implantation of semiconductor-based photodiodes. Durability of novel implant designs (2002) - The artificial silicon retina microchip for the treatment of vision loss from retinitis pigmentosa (2004)

 References

  1. ^US Patent 4,840,175, "METHOD FOR MODIFYING CORNEAL CURVATURE", granted June 20, 1989
  2. ^http://www.ascrs.org/Awards/Gholam-A-Peyman-MD.cfm
  3. ^http://www.ascrs.org/Awards/Gholam-A-Peyman-MD.cfm
  4. ^United States Patent and Trademark Office (hep://paot.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=0&f=S&l=50&TERM1= %22Peyman%3B+Gholam%22&FIELD1=&co1=AND&TERM2=&FIELD2=&d=PTXT)
  5. ^US Patent 4,840,175, "METHOD FOR MODIFYING CORNEAL CURVATURE", granted June 20, 1989
  6. ^American Academy of Cataract and Refrac.ve Surgery (hep://www.ascrs.org/Awards/ASCRS-Hall-of-Fame.cfm)
  7. ^Ophthalmic Surgery 11:325-329, 1980
  8. ^Ophthalmology 96:1160-1170, 1989
  9. ^Examples of these inlays can be found in US Patents: #6,203,538, granted March 2001, #6,217,571, granted April 2001, AND #6,280,470, all entitled, "INTRASTROMAL CORNEAL MODIFICATION";
    1. 6,221,067, granted April 2001, entitled "CORNEAL MODIFICATION VIA IMPLANTATION"; and others
  10. ^Journal of Refractive Surgery (hep://journalofrefrac.vesurgery.com/awards.asp)
  11. ^Ophthalmic Surg 3:29-31, 1972; Am J Ophthalmol 77:525-528, 1974; and Ophthalmic Surg 8:51-53,1977
  12. ^Arch Ophthalmol 86:548-551, 1971 and Surv Ophthalmol 17:29-40, 1972
  13. ^Am J Ophthalmol 80:767, 1975
  14. ^Irvine AR, O'Malley C (eds): Advances in Vitreous Surgery, Springfield, IL, Charles C. Thomas, pp 258-264, 1976 and In McPherson A (ed): New and Controversial Aspects of Vitreoretinal Surgery. St. Louis, CV Mosby, pp 169-175, 1977.
  15. ^Am J Ophthalmol 81:99-100, 1976.
  16. ^Ophthalmic Surg 7:96-97, 1976.
  17. ^Can J Ophthalmol 15:49-50, 1980.
  18. ^Arch Ophthalmol 100:1973, 1982.
  19. ^Retina 8:288, 1988
  20. ^Can J Ophthalmol 25:285-286, 1990.
  21. ^Ophthalmic Surg Lasers 27:246-247, 1996
  22. ^Am J Ophthalmol 133:568-569, 2002
  23. ^Am J Ophthalmol 135:236-237, 2003
  24. ^Am J Ophthalmol 13:199-201, 2003.
  25. ^Arch Ophthalmol 98:2062-2064, 1980.
  26. ^Arch Ophthalmol 99:2037-2038, 1981.
  27. ^Arch Ophthalmol 99:327, 1981
  28. ^Int Ophthalmol 9:43-44, 1986
  29. ^Arch Ophthalmol 104:608, 1986
  30. ^Retna 4:129-131, 1984
  31. ^Can J Ophthalmol 21:269-270, 1986
  32. ^Retna 7:32-33, 1987
  33. ^Ophthalmic Surg 18:185-186, 1987
  34. ^Arch Ophthalmol 110:718, 1992.
  35. ^Arch Ophthalmol 90(3):235-8, 1973
  36. ^Int Ophthalmol 10:149-151, 1987
  37. ^Can J Ophthalmol 22:276-278, 1987
  38. ^Ophthalmic Surg 20:286-293, 1989
  39. ^Surv Ophthalmol 39:375-395, 1995
  40. ^Invest Ophthalmol 11:115-121, 1972
  41. ^Arch Ophthalmol 92:216-218, 1974
  42. ^Invest Ophthalmol 14:707-710, 1975
  43. ^Ann Ophthalmol 9:479-484, 1977
  44. ^Ophthalmology 86:1024-1036, 1979
  45. ^Ophthalmology 90:840-847, 1983
  46. ^Int Ophthalmol 14:101-104, 1990.
  47. ^^Many peer-reviewed publications, including: Am J Ophthalmol 76:343-350, 1973; Arch Ophthalmol 92:149-154, 1974; Ophthalmic Surg 5:34-39, 1974; Am J Ophthalmol 80:764-765, 1975; et. al. �
  48. ^Can J Ophthalmol 9:463-467, 1974
  49. ^Ophthalmic Surg 14:494-498, 1983
  50. ^J Am Intraocul Implant Soc 8:357-360, 1982.
  51. ^Ophthalmic Surg 14:845-847, 1983 and Ophthalmic Surg 15:767-769, 1984
  52. ^Ophthalmic Surg 15:767-769, 1984
  53. ^Ophthalmic Surg 10(10):74-77, 1979
  54. ^Ophthalmic Surg 15:844-846, 1984
  55. ^Ophthalmic Surg 16:247-249, 1985
  56. ^Surv Ophthalmol 29:434-442, 1985
  57. ^Int Ophthalmol 8:193-198, 1985
  58. ^Re>na 9:232-236, 1989
  59. ^Ophthalmic Surg 15:666-669, 1984
  60. ^Arch Ophthalmol 102:1618-1621, 1984
  61. ^Arch Ophthalmol 102:1750, 1984
  62. ^Arch Ophthalmol 103:840-841, 1985
  63. ^Retna 7:80-83, 1987
  64. ^Int Ophthalmol 12:151-154, 1988
  65. ^Retina 12:261-264, 1992
  66. ^Ophthalmic Surg 17:155-156, 1986
  67. ^Int Ophthalmol 12:105-107, 1988
  68. ^Surg Lasers 33:140-144, 2002
  69. ^Invest Ophthalmol Vis Sci 27:1103-1106, 1986
  70. ^Ophthalmic Surg 19:252-256, 1988
  71. ^Int Ophthalmol 12:175-182, 1988
  72. ^Ophthalmic Surg 22:175-180, 1991
  73. ^Int Ophthalmol 16:109-113, 1992
  74. ^Ophthalmic Surg 11:325-329, 1980
  75. ^Ophthalmic Surg 15:496-501, 1984
  76. ^Int Ophthalmol 8:199-209, 1985
  77. ^Int Ophthalmol 10:213-220, 1987
  78. ^Int Ophthalmol 10:245-253, 1987
  79. ^Ophthalmic Surg 18:726-727, 1987
  80. ^Int Ophthalmol 11:159-62, 1988
  81. ^Int Ophthalmol 11:175-80, 1988

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http://en.wikipedia.org/wiki/Gholam_A._Peyman